We experienced three cases of endometrial carcinoma associated with chronic anovulation syndrome in young aged infertile women (28-30-31 years old). It is now apparent that polycystic ovarian disease and progesterone deficiency states belong to a
heterogenous gorup of disorders categorized as chronic anovulation syndrome, a spontaneous biologic experiment of unopposed secretion of estrogen by ovaries and it is belived to be the continuous estrogen stimulation of the endometrium,
unmodified
by
the cyclic effect of progesterone, that leads to endometrial hyperplasia and, in susceptible patient, to cancer, it is this concept of "unopposed estrogen" proposed by Gusberg, so we report three cases of endometrial cancer associated with
chronic
anovulation syndrome in young women with a brief review of literature.
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